We are already looking forward to another episode of the Tech Exchange, this time hearing about new developments in the electron microscopy field. The webinar is free to attend, but please register below.
Hugo Pérez-Garza from DENSsolutions B.V., the latest company to join our Industry Board, will present “In-situ Liquid Phase Transmission Electron Microscopy: A Powerful Tool for Single Particle Analysis, Cell Biology and Pharmaceutical Studies”.
The DENSsolutions Stream system is a plug-and-play system for in situ Liquid Phase Transmission Electron Microscopy (LPTEM) technology that uses a micro-electromechanical system (MEMS) device as a smart sample carrier. With Stream, you can perform in situ LPTEM studies under sub-nanometer resolution, while keeping your bio-sample in its native environment. Similarly, you can control the biochemistry on-the-fly and influence the kinetics of a biochemical reaction, while avoiding the liquid-air interface. Moreover, the system also enables high-throughput studies. This unlocks the possibility to observe biological processes as they truly occur as a function of different stimuli (e.g. temperature, pressure, biasing, flow rate, etc). As a result, research areas such as single particle analysis, cell biology, in-vivo studies of protein-protein interactions, real-time observations of organic crystal growth, cancer research and drug delivery are certainly some of the many fields where Stream can play a critical role.
Wim Voorhout from Thermo Fisher Scientific will present on “Cryo-FIB developments for tomography“.
Cryo-FIB/SEM microscopes have emerged as indispensable tools for cryo-electron microscopy. They allow thin electron-transparent cryo-lamellae to be prepared from vitrified biological samples, which can then be studied by means of electron-tomography. Our latest dedicated cryo-FIB microscopes offer the ability to perform lift-out under cryo-conditions and feature an integrated fluorescence microscope for localizing target sites within the frozen sample. A robust sample transfer system and a rotatable cryo-stage is at the center of a dedicated cryo-FIB/SEM instrument.